CANCER TEST
MELANOMA
MelanomArray
Information
Questions
Turn Around Time:
MelanomArray Basic: 6 business days*
MelanomArray Broad: 2 weeks*
* If the sample needs to be enriched to ensure successful results, we will contact you
I Choose MelanomArray Basic
MelanomArray Basic
With MelanomArray Basic we focus on testing for the presence of a mutation in the BRAF gene, in code V600.
Consult your Oncologist to get the best possible choice for you and personalized treatment. Further personalization of exams is possible.
MelanomArray Broad
With MelanomArray Broad we check for the presence of mutations in BRAF, KIT, NRAS genes. If requested, additional testing for NTRK1, NTRK2, NTRK3, ALK, ROS1 genes may be performed.
Consult your Oncologist to get the best possible choice for you and personalized treatment.
What is Clinical Utility of MelanomArray?
Finding a mutation in the BRAF gene is an indication for targeted therapy (BRAF inhibitors).
Similarly, if no mutation is found in the BRAF gene, finding a mutation in the KIT gene is an indication for targeted therapy (KIT inhibitors).
Finding a mutation in the NRAS gene is an indication for targeted therapy (MEK inhibitors)
Finding mutations in genes NTRK1, NTRK2, NTRK3, ALK, ROS1 is an indication for targeted therapy response with the corresponding inhibitors (eg TRK inhibitors)
The examination is conducted on the biopsy material or surgical specimen (paraffin block) on which your histology examination has been conducted.
At our vertically integrated Laboratory, we handle your sample in such a way as to minimize its unnecessary waste:
- The paraffin block is positioned if it is possible once in the microtome to obtain tissue incisions by experienced histotechnologists.
- Tissue sections are sequentially acquired in such a way as to provide immunohistochemistry diagnosis if required.
- Ensure maintenance of tissue sections for further molecular testing.
- Pathologists perform microdissection, in order to ensure the highest possible amount of cancer cells, removing all other necrotic cells or normal tissue that could affect the validity of the results.
- Directly, the molecular biologist treats the tissue in a completely controlled environment with next-generation sequencing (NGS), or polymerase chain reaction of real-time (Real-time PCR) for the detection of mutations in genes of interest.
Frequently Asked Questions (FAQ)
Finding a mutation in the BRAF gene is an indication for targeted therapy (BRAF inhibitors).
Similarly, if no mutation is found in the BRAF gene, finding a mutation in the KIT gene is an indication for targeted therapy (KIT inhibitors).
Finding a mutation in the NRAS gene is an indication for targeted therapy (MEK inhibitors)
Finding mutations in genes NTRK1, NTRK2, NTRK3, ALK, ROS1 is an indication for targeted therapy response with the corresponding inhibitors (eg TRK inhibitors).
The test is performed on the biopsy material or surgical specimen (paraffin block) on which your histological examination was conducted.
In case your sample is not already in MicroDiagnostics’ Ltd file. Contact us to arrange safe and fast transport to our laboratory. You will also need, easily and quickly, to complete the Consent Form.
During your visit to our laboratory, by bank card, bank deposit, or online interbank transaction
One of the primary concerns of microDiagnostics’ Ltd is the protection of your personal data as well as the strict adherence to the conditions protecting your genetic material and medical results.
In full compliance with the General Data Protection Regulation (GDPR) we ensure that you are aware and conscious for any examination will be conducted and we do not announce results via phone calls.