OncoGIST Array

Finding mutations in the KIT or PDGFRA genes, or not, is a criterion for selecting targeted therapy with TKI inhibitors.

The absence of expression of SDHB protein (IHC) indicates a mutation in the SDH gene. GIST tumors with a mutation in the SDH gene occur more frequently in the stomach, in young patients, have metastatic potential, may affect lymph nodes, and are characterized by slow growth. GIST tumors with a mutation in the SDH gene more often show resistance to Imatinib treatment.

The test is performed on the biopsy material or surgical specimen (paraffin blocks) on which your histological examination was performed as well.

In case your sample is not already in the microDiagnostics’ archive, contact us to undertake its safe and fast transfer to our laboratory.

You will also need to complete the Consent Form easily and quickly

In our vertical integrated Laboratory, we handle your sample in such way as to minimize its unnecessary waste:

• The paraffin block is positioned, if possible, once in the microtome to obtain tissue incisions by experienced histotechnologists.
• Incisions are sequentially acquired in such a way as to provide immunohistochemistry diagnosis and, if required.
• Ensure maintenance of incisions for further molecular testing.
• Pathologists perform microdissection, in order to ensure the highest possible amount of cancer cells, removing all other necrotic cells or normal tissue that could affect the validity of the results.
• Directly, the molecular biologist treats the tissue in a completely controlled environment with next-generation sequencing (NGS), or polymerase chain reaction of real-time (Real-time PCR) for the detection of mutations in genes of interest.

Gastrointestinal stromal tumors (GISTs) are unusual tumors of the gastrointestinal tract. These tumors begin from early forms of special cells in the wall of the gastrointestinal tract (GI), called intermediate Cajal cells (ICCs).
ICCs are cells of the autonomic nervous system, the part of the nervous system that regulates the body’s processes, such as digesting food. ICCs are called sometimes “GI’s” pacemakers because they send the muscles of the organs a signal to contract in order to transport and promote food and fluids.

More than half of GISTs develop in the stomach, while the rest develop in the small intestine, or anywhere along the GI tract.

5-year survival rates for patients with GIST tumor

(Based on people diagnosed with GIST between 2008 and 2014.)

SEER Στάδιο % 5year survival
Local 94%
Regional 83%
Distant 52%

* SEER = Surveillance, Epidemiology, and End Results

These numbers only apply to the cancer stage at first diagnosis. They do not apply later if cancer grows, spreads, or recurs after treatment.

Survival rates are grouped based on the extent of cancer, but also your age, overall health, cancer resection, the degree to which cancer responds to treatment, and other factors that may also affect your survival prospects.
People now diagnosed with GIST may have better prospects than these numbers. The treatments are improving over time and these numbers are based on people diagnosed and treated at least five years earlier.

The examination is performed on the biopsy material or surgical specimen (paraffin blocks) on which your histological examination was performed as well.

In case your sample is not already in the MicroDiagnostics’ Ltd archive, contact us immediately to undertake its safe and fast transfer to our laboratory.

Contact the molecular diagnostics service department:

Contact Number: 2310 23 22 72

By cash, bank card, or online interbank transaction

It usually takes 6 business days

In case more time is needed you will be informed in time.

One of the primary concerns of microDiagnostics’ Ltd is the protection of your personal data as well as the strict adherence to the conditions protecting your genetic material and medical results.

In full compliance with the General Data Protection Regulation (GDPR) we ensure that you are aware and conscious for any examination will be conducted and we do not announce results via phone calls.