CANCER TEST
BREAST CANCER
B.E.S.T. Basic & Broad
Information
Questions
Turn Around Time:
B.E.S.T. Basic: 2 weeks*
B.E.S.T. Broad: 2-2,5 weeks*
* If the sample needs to be enriched to ensure successful results, we will contact you
I Choose
B.E.S.T. Basic
With BEST Basic we focus on the 4 genes ( AKT1, ESR1, PIK3CA, PTEN ) that are statistically most frequently mutated in advanced or metastatic ER-positive, HER2-negative breast cancer, either at the time of diagnosis or for recurrent disease under endocrine therapy, in order to determine the suitability of the patient for specific targeted therapies. ESR1 testing is also used to monitor resistance during endocrine therapy.
Consult your Oncologist for the best choice and personalization for you. There is the possibility of further personalization of the tests.
In case your sample is not already at Microdiagnostics archive, please contact us immediately so that we can arrange for its safe and rapid transport to our laboratory. You will also need to quickly and easily complete the Consent Form.
The number and type of mutations examined is updated through a dynamic process in accordance with current scientific research. It should therefore be recognized that there is a possibility that the list of genes on the order form may have changed (genes added or removed) during the analysis of the sample in the laboratory.
B.E.S.T. Broad
With BEST Broad, in addition to the aforementioned 4 Basic genes, an additional 11 genes are added to the panel to test for the presence of mutations/rearrangements, providing an even more detailed and broad molecular profile of breast cancer. Microsatellite instability (MSI or MMR) is also tested .
The BEST Broad test additionally determines the Tumor Mutation Burden (TMB).
Consult your Oncologist for the best choice and personalization for you. There is the possibility of further personalization of the tests.
In case your sample is not already at Microdiagnostics archive, please contact us immediately so that we can arrange for its safe and rapid transport to our laboratory. You will also need to quickly and easily complete the Consent Form.
The number and type of mutations examined is updated through a dynamic process in accordance with current scientific research. It should therefore be recognized that there is a possibility that the list of genes on the order form may have changed (genes added or removed) during the analysis of the sample in the laboratory.
The BEST Basic & Broad test was developed according to the latest guidelines to assist clinicians in selecting the most appropriate, fully personalized treatment for each patient. BEST Basic & Broad is applied to breast cancers that relapse after first-line treatment, are inoperable or have metastasized.
The tests are performed on the surgical specimen (paraffin cubes) or the biopsy material (paraffin cube) from which your histological examination was performed or on the aspiration material (FNAB, EBUS) from which your cytological examination was performed. In our fully integrated Laboratory, the pathologist selects the most appropriate & representative paraffin cube, ensuring that the most appropriate sample will be used for the tests. Qualitative and quantitative parameters are checked.
In case your sample is not already at Microdiagnostics archive, please contact us immediately so that we can arrange for its safe and rapid transport to our laboratory. You will also need to quickly and easily complete the Consent Form.
Frequently Asked Questions (FAQ)
If you have breast cancer that has recurred after initial treatment, is not surgically treatable, or has metastasized, then the BEST Basic & Broad test can help clinicians choose the most appropriate and fully personalized treatment for you. This may include immunotherapy, targeted therapy, or chemotherapy.
The tests are performed on the surgical specimen (paraffin cubes) or the biopsy material (paraffin cube) from which your histological examination was performed or on the aspiration material (FNAB, EBUS) from which your cytological examination was performed. In our fully integrated Laboratory, the pathologist selects the most appropriate & representative paraffin cube, ensuring that the most appropriate sample will be used for the tests. Qualitative and quantitative parameters are checked.
In case your sample is not already at Microdiagnostics archive, please contact us immediately so that we can arrange for its safe and rapid transport to our laboratory. You will also need to quickly and easily complete the Consent Form.
Most of the time, the sample material we are called upon to handle is small because it has resulted from a minimally invasive method (needle biopsy, fluid aspiration, paraffin block with minimal material).
In our laboratory, Pathologists check in a timely manner whether the material to be examined is sufficient. If so, then a management algorithm is followed, with the aim of achieving the performance of multiple tests on the material (Immunohistochemistry, real-time PCR, NGS) in order to fully check the molecular profile of your tumor (proteins, genes, histological Grading).
In this case, and once sample enrichment manipulations have been exhausted, we contact your clinician to discuss alternative approaches in order to obtain the desired information to select the optimal treatment for you. Some examples:
- Performing an alternative test (e.g. Immunohistochemistry instead of PCR, or choosing Next Generation Sequencing (NGS)
- Performing Immunohistochemistry instead of FISH (Fluorescent In Situ Hybridization) and tubulin
- Possible blood sampling instead of tissue testing (liquid biopsy)
- Possible option to take a new biopsy or puncture
Contact us at 2310 23 22 72 and we will immediately assist you in quickly transporting the sample to our laboratory.
By cash, bank deposit, using a bank card or by online interbank deposit.
One of the primary concerns at Microdiagnostics is the protection of your personal data as well as the strict observance of the conditions for the protection of your genetic material and medical results.
In full compliance with the General Data Protection Regulation (GDPR), we ensure that any test conducted is done with your knowledge and consent and we do not communicate results over the phone.