SomArray Prostate

By analyzing many genes and proteins simultaneously, this test offers a detailed molecular profile of prostate cancer, based on which your Oncologist will select the best treatment for you individually.

The indications for performing SomArray Prostate are:

• Estimation of the probability that the patient carries mutations in genes associated with Lynch syndrome. Patients with Lynch syndrome have an increased probability of developing inherited forms of cancer such as breast, ovarian, prostate, pancreas, colon, endometrial, liver, kidney, bile duct.
• Low-risk patient with localized prostate cancer who has a family history of prostate cancer or histological examination with cancer morphology indicative of the test (intraductal carcinoma)
• Intermediate-risk patient with localized prostate cancer who has a family history of prostate cancer or histological examination with cancer morphology indicative of the test (intraductal carcinoma)
• High or very high risk patient with advanced prostate cancer.

The tests are performed on the surgical specimen (paraffin cubes) or the biopsy material (paraffin cube) from which your histological examination was performed or on the aspiration material (FNAB, EBUS) from which your cytological examination was performed. In our fully integrated Laboratory, the pathologist selects the most appropriate & representative paraffin cube, ensuring that the most appropriate sample will be used for the tests. Qualitative and quantitative parameters are checked.

In case your sample is not already at Microdiagnostics archive, please contact us immediately so that we can arrange for its safe and rapid transport to our laboratory. You will also need to quickly and easily complete the Consent Form.

In our fully integrated Laboratory, we handle your sample in such a way as to minimize its unnecessary waste:

• The paraffin cube is placed, if possible, once on the microtome for obtaining tissue sections, by experienced tissue technologists.
• Tissue sections are obtained sequentially in such a way as to ensure diagnosis and perform Immunohistochemistry if required.
• Ensuring preservation of tissue sections for further molecular testing.
• Pathologists perform microdissection to ensure the maximum amount of cancer cells possible, removing all other necrotic cells or normal tissue that could affect the validity of the results.
• The molecular biologist immediately processes the tissue in a fully controlled environment, using next-generation sequencing (NGS) or real-time polymerase chain reaction (Real-time PCR) to identify mutations in the genes of interest.

Depending on the case, there are various treatment options, each of which has benefits, risks, and contraindications. These treatments are:

• Active monitoring
• Surgery (radical prostatectomy)
• Radiotherapy (external or brachytherapy)
• Cryotherapy (cryosurgery)
• Hormonal therapy
• Chemotherapy
• Treatments for bone metastases
• High-frequency ultrasound therapy

The indications for performing SomArray Prostate are:

• Estimation of the probability that the man carries mutations in genes associated with Lynch syndrome. Patients with Lynch syndrome have an increased probability of developing inherited forms of cancer such as breast, ovarian, prostate, pancreas, colon, endometrial, liver, kidney, bile duct.
• Low-risk patient with localized prostate cancer who has a family history of prostate cancer or histological examination with cancer morphology indicative of the test (intraductal carcinoma)
• Intermediate-risk patient with localized prostate cancer who has a family history of prostate cancer or histological examination with cancer morphology indicative of the test (intraductal carcinoma)
• High or very high risk patient with advanced prostate cancer.

The tests are performed on the surgical specimen (paraffin cubes) or the biopsy material (paraffin cube) from which your histological examination was performed or on the aspiration material (FNAB, EBUS) from which your cytological examination was performed. In our fully integrated Laboratory, the pathologist selects the most appropriate & representative paraffin cube, ensuring that the most appropriate sample will be used for the tests. Qualitative and quantitative parameters are checked.

In case your sample is not already at Microdiagnostics archive, please contact us immediately so that we can arrange for its safe and rapid transport to our laboratory. You will also need to quickly and easily complete the Consent Form.

Most of the time, the sample material we are called upon to handle is small because it has resulted from a minimally invasive method (needle biopsy, fluid aspiration, paraffin block with minimal material).

In our laboratory, Pathologists check in a timely manner whether the material to be examined is sufficient. If so, then a management algorithm is followed, with the aim of achieving the performance of multiple tests on the material (Immunohistochemistry, real-time PCR, NGS) in order to fully check the molecular profile of your tumor (proteins, genes, histological Grading).

In this case, and once sample enrichment manipulations have been exhausted, we contact your clinician to discuss alternative approaches in order to obtain the desired information to select the optimal treatment for you. Some examples:

• Performing an alternative test (e.g. Immunohistochemistry instead of PCR, or choosing Next Generation Sequencing (NGS)
• Performing Immunohistochemistry instead of FISH (Fluorescent In Situ Hybridization) and tubulin
• Possible blood sampling instead of tissue testing (liquid biopsy)
• Possible option to take a new biopsy or puncture

Contact us at 2310 23 22 72 and we will immediately assist you in quickly transporting the sample to our laboratory.

By cash, bank deposit, using a bank card or by online interbank deposit

One of the primary concerns at Microdiagnostics is the protection of your personal data as well as the strict observance of the conditions for the protection of your genetic material and medical results.

In full compliance with the General Data Protection Regulation (GDPR), we ensure that any test conducted is done with your knowledge and consent and we do not communicate results over the phone.