PredictArray Thyroid

PredictArray Thyroid is recommended in the following cases:

• for patient treatment who seem to have nodules in the thyroid gland, with cytological examination unspecified or suspected of malignancy.
• the mutation detection in the BRAF gene is found in aggressive forms of papillary thyroid carcinoma (PTC) and is associated with a worse prognosis.
• mutation detection in the BRAF gene is associated with recurrence of the disease after the surgery
• mutation detection in the BRAF gene is associated with lymph node metastases

PredictArray Thyroid is performed on the biopsy material (paraffin block, FFPET) or on the FNAB cell block in which your histological or cytological examination was conducted.

Contact us directly to undertake its safe and fast transport to our laboratory.

In our vertical integrated Laboratory, we handle your sample in such way as to minimize its unnecessary waste:

• The paraffin block (FFPET) or CELL BLOCK (produced by FNAB reception) is placed once in the microtome to obtain tissuesections by experienced histotecnologists.
• Incisions are sequentially acquired in such a way as to provide immunohistochemistry diagnosis and if required.
• Ensure maintenance of incisions for further molecular testing.
• Pathologists perform microdissection, in order to ensure the highest possible amount of cancer cells, removing all other necrotic cells or normal tissue that could affect the validity of the results.
• Directly, the molecular biologist treats the tissue in a completely controlled environment with next-generation sequencing (NGS), or polymerase chain reaction of real-time (Real-time PCR) for the detection of mutations in genes of interest.

Most thyroid cancers are highly treatable, although about 5% of cases (myeloid and regenerative carcinoma) are more aggressive and tend to spread to other organs. Treatment depends on the histological type of the cancerous tumor, its size, and the presence or absence of an extra-thyroid disease.

• Surgical treatment

• Administration of radioactive iodine (I-131) after surgery for differentiated thyroid carcinoma

• Hormone therapy with thyroxine

• Treatment with tyrosine kinase inhibitors
have been used in several clinical trials as a targeted anti-cancer treatment in undifferentiated thyroid neoplasms.

Your clinician has performed a fine needle aspiration (FNAB) to take cells from the nodule(s) in your thyroid to see if the nodule(s) is/are benign or cancerous. If the cytology result is indeterminate, then PredictArray Thyroid can help to understand whether the nodule is benign or not. The test checks for the presence of mutations in specific genes.

The tests are performed on the surgical specimen (paraffin cubes) or the biopsy material (paraffin cube) from which your histological examination was performed or on the aspiration material (FNAB, EBUS) from which your cytological examination was performed. In our fully integrated Laboratory, the pathologist selects the most appropriate & representative paraffin cube, ensuring that the most appropriate sample will be used for the tests. Qualitative and quantitative parameters are checked.

In case your sample is not already in the Microdiagnostics archive, please contact us immediately so that we can arrange for its safe and rapid transport to our laboratory. You will also need to quickly and easily complete the Consent Form.

Most of the time, the sample material we are called upon to handle is small because it has resulted from a minimally invasive method (needle biopsy, fluid aspiration, paraffin block with minimal material).

In our laboratory, Pathologists check in a timely manner whether the material to be examined is sufficient. If so, then a management algorithm is followed, with the aim of achieving the performance of multiple tests on the material (Immunohistochemistry, real-time PCR, NGS) in order to fully check the molecular profile of your tumor (proteins, genes, histological Grading).

In this case, and once sample enrichment manipulations have been exhausted, we contact your clinician to discuss alternative approaches in order to obtain the desired information to select the optimal treatment for you. Some examples:

• Performing an alternative test (e.g. Immunohistochemistry instead of PCR, or choosing Next Generation Sequencing (NGS)
• Performing Immunohistochemistry instead of FISH (Fluorescent In Situ Hybridization) and tubulin
• Possible blood sampling instead of tissue testing (liquid biopsy)
• Possible option to take a new biopsy or puncture

Contact us at 2310 23 22 72 and we will immediately assist you in quickly transporting the sample to our laboratory.

By cash, bank card, bank deposit, or Online interbank deposit.

One of the primary concerns of Microdiagnostics is the protection of your personal data as well as the strict observance of the conditions for the protection of your genetic material and medical results.

In full compliance with the General Data Protection Regulation (GDPR), we ensure that any test conducted is done with your knowledge and consent and we do not communicate results over the phone.